Nicki Aycox was the daughter of Margaret Aycox and Gary Aycox. She was born in Hennessey, Oklahoma. There is no information about them on the internet.

As a child, Aycox played the piano and sang in beauty pageants. Her early appearances include 3rd Rock from the Sun, USA High, Boy Meets World, The X-Files and a recurring role in Providence.

In July 2009, Aycox began to portray the character Jaimie Allen (an undercover LAPD police officer) in the TNT action/drama series, Dark Blue. It ended its run on September 15, 2010.

In 2015, Aycox released her debut EP, Red Velvet Room, which contained five songs from her original music.